Proton pump inhibitors in systemic sclerosis: a reappraisal to optimise treatment of gastro-oesophageal reflux disease

نویسندگان

چکیده

Gastro-oesophageal reflux disease (GERD) is associated with substantial morbidity in patients systemic sclerosis. Although the introduction of proton pump inhibitors (PPIs) into clinical care represents a major achievement management gastro-oesophageal problems sclerosis, PPIs are seldom fully effective and use maximum PPI doses very frequent practice. However, there little evidence to support empirical This scarcity especially relevant regards safety concerns long-term exposure, which have been raised general population. The purpose this Viewpoint highlight beneficial impact on GERD while considering potential adverse effects patient Furthermore, we unmet needs people sclerosis propose an agenda for future research optimise safe

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Endoscopic treatment of gastro-oesophageal reflux disease.

Gastro-oesophageal reflux disease is a common chronic disorder which has a severe effect on the patient's quality of life. In view of the high cost of medical therapy and the limitations of surgery, a variety of endoscopic techniques have been developed for the treatment of this condition, and these have shown apparently encouraging results, at least in the short- term. However, several inconsi...

متن کامل

Meta-analysis: the efficacy of proton pump inhibitors for laryngeal symptoms attributed to gastro-oesophageal reflux disease.

BACKGROUND Many investigators have proposed an association between gastro-oesophageal reflux disease and laryngo-pharyngeal symptoms, suggesting that medical or surgical therapy for reflux may be useful. AIM To perform a meta-analysis assessing the effectiveness of medical or surgical therapy for reflux disease in adult patients with laryngeal or pharyngeal symptoms presumed to be due to gast...

متن کامل

Gastro-oesophageal reflux disease.

Gastro-oesophageal reflux disease is one of the most common disorders of the gastrointestinal tract. Over past decades, considerable shifts in thinking about the disease have taken place. At a time when radiology was the only diagnostic test available, reflux disease was regarded as synonymous with hiatus hernia. After the advent of the flexible endoscope, reflux disease was, for a period, equa...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: The Lancet Rheumatology

سال: 2022

ISSN: ['2665-9913']

DOI: https://doi.org/10.1016/s2665-9913(22)00183-7